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Everyone that has experienced the "bloat" from creatine knows that creatine monohydrate is poorly absorbed by the
body. Creatine's effectiveness is dependant upon the cells ability to absorb it. The poor absorption rate of regular
creatine monohydrate requires the creatine user to ingest large dosages of creatine to achieve desired effect. This in
turn can create unwanted side effects such as stomach bloating, water retention, and diarrhea.
Creatine works by drawing water into the cell. Since most supplemental creatine monohydrate is not absorbed, the
unabsorbed creatine can hang outside the target cell with the water it was initially trying to draw in. The end result is the
notorious "creatine bloat."
With the sports nutrition industry constantly evolving, scientific researchers are always on the quest for the "next big
thing". Well folks, the next generation of creatine is here. It's called creatine ethyl-ester, the most innovative creatine
known to man.
Before we bombarded you with technical information, let's take a moment for a refresher course in Biochemistry. All
living cells have a lipid bilayer. This is a membrane composed only of lipid molecules. The lipid bilayer is the
foundation of all biological membranes, and is a prerequisite of cell-based life. Passive permeation is a process that
describes the diffusion of a substance across a cell membrane through the use of lipids as transport mechanisms.
Esters are organic compounds that are formed by esterification - the reaction of carboxylic acid and alcohols. The most
common esters found in nature are in the fat tissue in animals. That sounds familiar right? Now let's get on to the
interesting stuff.
Regular creatine monohydrate is semi-lipophilic. This means that it inefficiently uses fat as a transport mechanism. The
esterification of substances will increase their lipophilic abilities. Therefore, esterified creatine will use fat more efficiently
to permeate the cell wall and exert its effects upon cellular function vs. unesterified creatine monohydrate.What does
this mean? Well it's simple. The absorption of esterified creatine is significantly increased up to 30-40 times more than
creatine monohydrate. Side effects such as the infamous creatine bloat, cramping, diarrhea and water retention are not
experienced! Creatine ethyl-ester is so efficient, that results can be achieved with a smaller serving size. Say goodbye
to the standard 5-10 gram servings per day with regular creatine monohydrate. Of all the athletes that have tried the
Pure Advantage creatine ethyl-ester, results were reported within 30-45 minutes upon ingestion. Pure Advantages'
creatine ethyl-ester is in a convenient vegetable capsule and does not require the use of expensive sugar laden
transport systems. Creatine ethyl-esters rapid absorption and nearly 100% utilization has raised the bar for creatine
supplementation.
Creatine Ethyl Ester Complex References
1. Racette SB. Creatine supplementation and athletic performance. J Orthop Sports Phys Ther. 2003 Oct;33(10):615-21.
2. Kreider, R.B., 1999. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Medicine 27:97-110.
3. Becque, M.D., et al. 2000. Effects of oral creatine supplementation on muscular strength and body composition. Medicine and Science in Sports and Exercise 32: 654-658.
4. Ingwal JS, Weiner CD, Morales MF, Davis E, Stockdale FE: Specificity of creatine in the control of muscle protein synthesis. J Cell Biol 63:145-151, 1974.
5. Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003 Nov;17(4):822-31.
6. Kambis KW, Pizzedaz SK. Short-term creatine supplementation improves maximum quadriceps contraction in women. Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):87-96.
7. Gill ND, Hall RD, Blazevich AJ. Creatine serum is not as effective as creatine powder for improving cycle sprint performance in competitive male team-sport athletes. J Strength Cond
Res. 2004 May;18(2):272-5.
8. Rawson, E.S., et al. 1999. Effects of 30 days of creatine ingestion in older men. European Journal of Applied Physiology 80: 139-144.
9. Sosin D.M., Sniezek J.E., Thurman D.J.. Incidence of mild and moderate brain injury in the United States, 1991. Brain Inj 1996 Jan;10(1):47-54.
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